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4)33)26-13-14-27-23(10-7-16-30(26
Smiles: NCCOCCOCCOCCC(=O)NC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O
6R)-2-(6-chloropyridin-3-yl)-1
Acalabrutinib
exhibits high binding affinity to melanocortin 1 receptor (MC1R) with a Ki of 0
A-366 044SB069 4)33)26-13-14-27-23(10-7-16-30(26A 366 is a potent, highly selective, peptide competitive histone methyltransferase G9a inhibitor with IC50s of 3. 3 and 38 nM for G9a and GLP (EHMT1), respectively. A 366 shows >1000 fold selectivity over 21 other methyltransferases. A 366 is also a potent, nanomolar inhibitor of the Spindlin1 H3K4me3 interaction (IC50=182. 6 nM). A 366 displays high affinity at human histamine H3 receptor (Ki=17 nM) and shows subtype selectivity among subsets of the
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